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Rethinking How Cancer Cells Evade Targeted Therapy

Through decades of biobanking at UCSF, researchers were able to comprehensively map intra-cellular signaling in the cells of recurrent glioblastoma, identifying novel cell-extrinsic therapeutic targets.

microscope image of green glioblastoma cells and blue brain organoids

Down Syndrome, Like Alzheimer’s, Is a Double-Prion Disorder

The brains of people with Down syndrome develop the same neurodegenerative tangles and plaques associated with Alzheimer’s disease and frequently demonstrate signs of the neurodegenerative disorder in their forties or fifties. A new study shows that these tangles and plaques are driven by the same amyloid beta (Aß) and tau prions as Alzheimer’s disease.

Microscopy of blue cells with clumps of yellow proteins, indicating contact with prion forms of amyloid beta

$147M Grant Will Address Imbalances in Alzheimer’s Study

A $147 million grant will expand diversity among Alzheimer’s disease research participants, and involve partners from UCSF, the San Francisco VA Medical Center, and the Northern California Institute for Research and Education.

An MRI technician looks at brain scans in the foreground, while a subject is inside an MRI