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Administering stem cell or enzyme therapy in utero may be a path to alleviating some congenital diseases that often result in losing a pregnancy, according to a new study in mice by UCSF researchers. They showed that stem cells can enter the fetal brain during prenatal development and make up for cells that fail to make an essential protein.
Advances in medicine and public health have dramatically extended the lifespan of hearts, lungs, and other vital organs. But for women, the ovaries remain a stubborn exception. That may soon change, says fertility expert Marcelle Cedars.
International team of researchers report progress in using stem cells to develop new therapies for Pelizaeus-Merzbacher disease, a rare genetic condition affecting boys that can be fatal before 10 years of age.
In a paper researchers describe a technique that uses a special version of CRISPR developed at UCSF to systematically alter the activity of genes in human neurons generated from stem cells, the first successful merger of stem cell-derived cell types and CRISPR screening technologies.