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Dementia Spreads via Connected Brain Networks

Scientists used maps of brain connections to predict how brain atrophy would spread in individual patients with frontotemporal dementia, adding to growing evidence that the loss of brain cells associated with dementia spreads via the synaptic connections between established brain networks.

an illustration of brain synapses

Genetically Tailored Instruction Improves Songbird Learning

UCSF study conducted in songbirds shows that what at first appear to be genetic constraints on birds’ song learning abilities could be largely eliminated by tailoring instruction to better match the birds’ inborn predispositions.

Brainard Bengalese Finches

Tweaked CRISPR in Neurons Gives Scientists New Power to Probe Brain Diseases

In a paper researchers describe a technique that uses a special version of CRISPR developed at UCSF to systematically alter the activity of genes in human neurons generated from stem cells, the first successful merger of stem cell-derived cell types and CRISPR screening technologies.

microscopic image of neurons