 Todd
P. Margolis, MD, PhD
Foundation Director, and
Director, Ralph and Sophie Heintz
Research Laboratory
Other Activities
Professor, Department of Ophthalomology, UCSF
Contact Information
95 Kirkham Box 0944
San Francisco, CA 94143-0944
Phone: 415-476-1442
todd.margolis@ucsf.edu
Related Link
Biomedical
Sciences Graduate Program
Education
MD: University of California, San Francisco
PhD: Neuroscience, University of California, San Francisco
Residency: Ophthalmology, University of California, San Francisco
Fellowships: Cornea, Uveitis and External Disease, Jules Stein
Eye Institute, UCLA, and
Cornea, Uveitis, and External Disease, Francis I. Proctor,
UCSF
Postdoctoral: Cornea and External Diseases, Department of
Microbiology and Immunology, UCLA
Internship: Internal Medicine, San Francisco Children's Hospital
Research Interests
RALPH AND SOPHIE HEINTZ LABORATORY RESEARCH
The primary focus of the Margolis laboratory is research on the cellular and molecular mechanisms that regulate the establishment and maintenance of latent neuronal infection with herpes simplex virus (HSV). Ongoing research is aimed at documenting the role of the immune system and neuronal gene expression in the establishment and maintenance of HSV latency, as well as the role of the HSV latency associated transcript (LAT). The ultimate goal of this work is to gain enough of an understanding about the regulation of HSV latent infection that therapeutic interventions can be devised to eliminate latent infection or prevent viral reactivation. A second line of investigation focuses on the role of mutations in the human AIRE gene in the pathogenesis of HLA-B27 associated iritis and Sjögren’s syndrome.
Representative Publications
Warren JF, Abbott RL, Yoon MK, Crawford JB, Spencer WH,
Margolis TP. A new mutation (Leu569Arg) within exon 13 of
the TGFBI (BIGH3) gene causes lattice corneal dystrophy type
I. Am J Ophthalmol. 2003. 136(5):872-8.
Pepose JS, Margolis TP, LaRussa P, Pavan-Langston D. Ocular
complications of smallpox vaccination. Am J Ophthalmol. 2003.
136(2):343-52.
Strauss EC, Warren JF, Margolis TP, Holsclaw DS. Diagnosis
of conjunctival B-cell lymphoma by polymerase chain reaction
heteroduplex analysis. Am J Ophthalmol. 2003. 136(1):207-9.
Ellison AR, Yang L, Cevallos AV, Margolis TP. Analysis of
the herpes simplex virus type 1 UL6 gene in patients with
stromal keratitis. Virology. 2003. 310(1):24-8.
Kuo IC, Imai Y, Shum C, Martin DF, Kuppermann BD, Margolis
TP. Genotypic analysis of cytomegalovirus retinitis poorly
responsive to intravenous ganciclovir but responsive to the
ganciclovir implant. Am J Ophthalmol. 2003. 135(1):20-5.
Sherman MD, Feldman KA, Farahmand SM, Margolis TP. Treatment
of conjunctival squamous cell carcinoma with topical cidofovir.
Am J Ophthalmol. 2002. 134(3):432-3.
Alrawi AM, Chern KC, Cevallos V, Lietman T, Whitcher JP,
Margolis TP, Cunningham ET Jr. Biotypes and serotypes of Haemophilus
influenzae ocular isolates. Br J Ophthalmol. 2002. 86(3):276-7.
Feldman LT, Ellison AR, Voytek CC, Yang L, Krause P, Margolis
TP. Spontaneous molecular reactivation of herpes simplex virus
type 1 latency in mice. Proc Natl Acad Sci U S A. 2002 . ;99(2):978-83.
Naseri A, Margolis TP. Varicella zoster virus immune recovery
stromal keratitis in a patient with AIDS. Br J Ophthalmol.
2001. 85(11):1390-1.
Grigg ME, Ganatra J, Boothroyd JC, Margolis TP. Unusual
abundance of atypical strains associated with human ocular
toxoplasmosis. J Infect Dis. 2001. 84(5):633-9.
Summers BC, Margolis TP, Leib DA. Herpes simplex virus type
1 corneal infection results in periocular disease by zosteriform
spread. J Virol. 2001. 75(11):5069-75.
Kuo IC, Margolis TP, Cevallos V, Hwang DG. Aspergillus fumigatus
keratitis after laser in situ keratomileusis. Cornea. 2001.
20(3):342-4. Complete
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