Matthew "Max" Krummel, Ph.D.

Associate Professor of Pathology
Principal Investigator

513 Parnassus Avenue
Room HSW-512, Box 0511
San Francisco, CA 94143-0511
phone: 415.514.3130
fax: 415.514.3165

Education:
Aug. 1989-May 1995: University of California at Berkeley, Department of Molecular and Cell Biology. Ph.D. Immunology.
Aug. 1985-May 1989: University of Illinois, School of Liberal Arts and Sciences, B.S. Honors Biology and B.S. Chemistry.
Aug. 1987-May 1988: Exchange Student, Department of Chemistry ,University College, London, England.
Aug. 1980-May 1985: University of Illinois High School, Urbana, Illinois.

Employment:
Aug. 2001-Present: Assistant Professor, Department of Pathology, University of California at San Francisco.
Nov.1997-Aug. 2001: Postdoctoral Fellow, Beckman Institute, Stanford University. Advisor: Dr. Mark M. Davis.
Aug.1996-Sept.1997: Postdoctoral Fellow, Walter and Eliza Hall Institute, Melbourne Australia. Advisors: Dr. Bill Heath and Dr. Ken Shortman.
June 1995-May 1996: Postdoctoral Fellow, UC Berkeley. Advisor: Dr. James P. Allison.
Aug. 1989-May 1995: Graduate Research Assistant, UC Berkeley. Advisor: Dr. James Allison.
Summer 1988: Stagiare (Technician), UGM, Institut Pasteur. Advisors: Dr. Julian Davies and Dr. Tom Holt.
Summer 1987: HHMI Summer Fellow, UTHSC Dallas. Advisor: Dr. Flora Katz.

Professional Associations:
2003-Present: American Association of Investigative Pathology
1997-Present: American Association of Immunologists
1991-Present: American Association for the Advancement of Science

Honors, Awards, and Patents:
2004-2007: Leukemia and Lymphoma Foundation, Career
2004-2007: Cancer Research Institute, Investigator Award.
1997-2000: NRSA Postdoctoral Fellowship, National Institutes of Health.
1996-1997: Postdoctoral Fellowship, Juvenile Diabetes Foundation International.
1998: PATENT: J.P. Allison, D.R. Leach, and M.F. Krummel. Blockade of Lymphocyte Down-Regulation Associated with CTLA-4 Signaling. US Patent 5,855,887, 5,811,097.
1989: Luce scholars competition finalist, Henry Luce Foundation.
1986: James scholar, University of Illinois.
1985: Illinois State Scholar, National Merit scholar, Westinghouse Science Award.

Professional Service:
July 2005-Present: Associate Editor, Immunity.
Ongoing: Peer Reviewer for: Immunity, PNAS, Journal of Immunology, Trends in Molecular Medicine, Current Issues in Molecular Biology, Blood.
March 2004: Ad hoc reviewer for US-Israeli Binational Science Foundation
June 2003: Ad hoc reviewer for NIH/Aly Study Section
Sept 2003: Ad hoc reviewer for The Wellcome Trust

Publications:
Krummel, M.F. and Allison, J.P. 1995. CD28 and CTLA-4 deliver opposing signals which regulate the response of T cells to stimulation. Journal of Experimental Medicine. 182:459-465.

Allison, J.P. and Krummel, M.F. 1995. The yin and yang of T cell costimulation. Science. 270:932-933.

Krummel, M.F., Sullivan, T.J. and Allison, J.P. 1995. Superantigen responses and costimulation: CD28 and CTLA-4 have opposing effects on T cell expansion In Vitro and In Vivo. Int.Immunol. 8:101-105.

Krummel, M. and Allison, J.P. "B7 mediated costimulation of T cells: CTLA-4 can deliver inhibitory signals." 1995 In Genetic models of immune and inflammatory diseases, Abbas, A.K. and Flavell, R.A. eds. Springer Verlag: New York.

Chambers, C.A., Krummel, M.F., Boitel, B., Hurwitz, A., Sullivan, T.J., Fournier, S., Cassell, D., Brunner, M. and Allison, J.P. 1996. The role of CTLA-4 in the regulation and initiation of T cell responses. Immunological Reviews. 153:27-46.

Leach, D.R., Krummel, M.F. and Allison, J.P. 1996. Enhancement of antitumor immunity by CTLA-4 blockade. Science. 271:1734-1736.

Krummel, M.F. and Allison, J.P. 1996. CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells. Journal of Experimental Medicine. 183:2533-2540.

Winkel, K.D., Kronin, V., Krummel, M.F. and Shortman, K. 1997. The nature of the signals regulating CD8 T cell proliferative responses to CD8a+ or CD8a- dendritic cells. European Journal of Immunology. 27:3350-3359.

Hurwitz, A.A., Sullivan, T.J., Krummel, M.F., Sobel, R.A. and Allison, J.P. 1997. Specific blockade of CTLA-4/B7 interactions results in exacerbatedclinical and histological disease in an actively-induced model of experimental allergic encephalomyelitis. J. Neuroimmunology. 73:57-62.

Allison, J.P., Chambers, C., Hurwitz, A., Sullivan, T., Boitel, B. Fournier, S. Brunner, M., Krummel, M.F. 1998. A Role for CTLA-4-mediated inhibitory signals in peripheral T cell tolerance? Novartis Foundation Symposium. 215:98-102.

Allison, J., Stephens, L., Kay, T.W., Kurts, C., Heath, W.R., Miller, J.F. and Krummel, M.F. 1998. The threshhold for autoimmune T cell killing is influenced by B7.1. European Journal of Immunology. 28:949-960.

Kurts, C., Carbone, F.R., Krummel, M.F., Miller, J.F.A.P. and Heath, W.R. 1998. CD30 signalling protects against CD8 T cell-mediatedautoimmune diabetes. Nature. 398:341-4.

Krummel, M.F., Heath, W.R. and Allison, J. 1999. Differential coupling of second signals for cytotoxicity and proliferation in CD8+ T cell effectors: Amplification of the lytic potential by B7. J. Immunol. 163:2999-3006.

Davis,M.M., Wülfing,C., Krummel, M.F., Savage,P., Xu,J., and Chieh,H-Y. 2000. "Visualizing T cell activation." In Signaling & Gene Expression in the Immune System. Cold Spring Harbor Symposia on Quantitative Biology, Volume LXIV.

Krummel, M.F., Wülfing,C., Sumen, C., and Davis, M.M. 2000. Thirty six views of T cell recognition. In Phil. Trans. R. Soc. Lond. 355:1071-1076.

Krummel, M.F., Sjaastad, M.D., Wülfing, C., and Davis, M.M. 2000. Differential clustering of CD4 and CD3z during T cell recognition. Science. 289:1349-1352.

Krummel, M.F.and Davis, M.M. 2002 Dynamics of the Immunological Synapse: Finding, Establishing and Solidifying a Connection. Curr. Op. Immunol. 14:66-74.

Richie, L.I., P.J.R. Ebert, Wu, L.C., Krummel, M.F., Owen, J.J.T. , and Davis, M.M. 2002. Imaging synapse formation during thymocyte selection: inability of CD3z to form a stable central accumulation during negative selection. Immunity. 16:595-606.

Moss,W.C., Irvine,D.C, Davis,M.M., and Krummel, M.F. 2002. Quantifying Signaling-Induced Reorientation of Cell Membrane and TCRs During Immunological Synapse Formation. PNAS. 99:15024-15029.

Richie Ehrlich,L.I., Ebert, P.J.R. Krummel, M.F., Weiss,A. and Davis, M.M. 2002. Dynamics of p56lck translocation to the T cell immunological synapse following agonist and antagonist stimulation. Immunity. 17:809-822.

Andres,P.G., Howland,K.C., Dresnek,D. Edmondson, S., Abbas,A.K., and Krummel, M.F. 2004. CD28 signals in the immature immunological synapse. J Immunol 172, 5880-6.

Jacobelli, J. Chmura, S.A., Buxton,D.B., Davis , M.M. and Krummel, M. F. 2004. Class II Myosin Heavy Chain 2A/MyH9 Is Involved in the T Cell Stop Signal but is not Required for Synapse Formation. Nature Immunology 5, 531 - 538.

Jacobelli, J., Andres, P.G., Boisvert, J., and Krummel, M.F. 2004. New Views of the Immunological Synapse: Variations in Assembly and Function. Curr Opin Immunol 16, 345-52.

Boisvert, J., Edmondson, S. and Krummel, M.F. 2004. Immunological Synapse Formation Licenses CD40-CD40L Accumulations at T-APC Contact Sites. J. Immunol. 173, 3647-3652.

Tooley,A.J., Jacobelli, J., Moldovan, M-C., Douglas, A., and Krummel, M.F. 2005. T cell Synapse Assembly: Proteins, Motors and the Underlying Cell Biology. Seminars in Immunology, 17, 65-75.

Okada, T. Miller, M.J., Parker, I., Krummel, M.F., O’Garra,A. Cahalan,M.D., Cyster, J.G. 2005. Antigen-engaged B cells undergo directional migration to the T cell zone and form motile conjugates with helper T cells. PLOS Biology 3 1-13.

Friedman, R.S., Jacobelli, J., Krummel, M.F. 2005. Mechanisms of T cell Motility and Arrest: Deciphering the Relationship between Intra- and Extracellular determinants. Seminars in Immunology.

Moldovan, M-C., Boisvert, J., Sabbagh, L., Sékaly, R-P*, and Krummel, M.F.* (*co-last authors) Multi-step Triggering of T cell activation via CD4 Dimers. Submitted.

Tang, Q., Adams, J.Y., Tooley, A.J., Bi, M., Serra, P., Santamaria, P., Krummel, M.F.* and Bluestone, J.A.* (*co-last authors) Visualizing regulatory T cell control of autoimmune response in NOD diabetic mice. Nature Immunology, In Press.

Friedman, R.S., Jacobelli, J. and Krummel, M. F. Surface-bound Chemokines Capture T cells For Synapse Formation. In preparation.