Richard C.K. Jordan
The focus of my translational research program has been the
characterization of molecular events that occur during the progression
of oral precancer to oral cancer and if these changes can be used to
predict oral cancer development.
My group was the first to characterize changes in critical cell cycle
regulators including p27kip1
and skp2 in oral
precancer and cancer. We were also the first to show differing patterns
of p53 protein
expression in oral precancer and to fully describe changes in the
entire p53 gene in head and neck cancers and their impact on radiation
therapy. We have also characterized alterations in the CDKN2A gene and p14ARF in oral precancer and
cancer. We use many state-of-the-art
molecular pathology methods including
laser capture microdissection (LCM) to harvest tumor
cells, cDNA microarrays
to analyze global gene expression and real-time, and TaqMan PCR to analyze mRNA in
routinely processed tissue sections.
As part of the UCSF Oral
Cancer Program Project, I am directing the Tissue Bank and Pathology Core
that provides fundemental support for the oral cancer research
projects. The Core represents a network of clinicians, pathologists,
and technical staff whose aims are, 1) to collect, identify, and make
available to researchers, human oral cancerous tissues,
2) to develop a patient data-base for correlation of patient outcome
with molecular tumor markers, and 3) to collaborate with the
Program investigators relative to histopathology and
immunohistochemistry.
Darren P. Cox Coming
soon!
Troy E. Daniels
My principal research interests are in studying the salivary
gland pathology of the autoimmune disease
Sjögren's syndrome (SS) and the clinical
diagnosis and oral sequelae of that chronic and complex disease. I have
actively participated in developing international criteria for
diagnosing SS for several years. With contributions from colleagues, I
have developed comprehensive
clinical guidelines for oral treatment and dental caries
prevention in patients with SS (and other causes of chronic dry mouth),
which have been adopted by the national patient support group for SS
patients and widely distributed internationally. I also continue to be
interested in the diagnostic applications of direct immunofluorescence
microscopy to diagnosing chronic inflammatory mucosal diseases.
John S. Greenspan
My research interests center on the etiology, pathogenesis,
epidemiology, and management of oral soft tissue diseases, notably
those associated with HIV
infection and other causes of immunosuppression, as well as aphthous ulcers, Sjögren's syndrome
, and oral cancer/precancer.
My long-term goal is to understand these diseases in order to prevent
and treat them. My group has been responsible for major portions of the
growing body of information on oral aspects of AIDS, including the
discovery of hairy leukoplakia
and its causation by the
Epstein-Barr virus , the significance of that lesion and
of oral candidiasis
as predictors of progression of HIV disease, and the apparently
protective effects of salivary
gland disease in the HIV-infected population. My work has
spanned the spectrum from molecular biology and electron microscopy
cytochemistry, through clinical epidemiology and therapeutic trials, to
public health and policy issues. I have been fortunate to see much of
this work applied in the mainstream of AIDS science, care, and policy.
[UCSF Home
]
[ Campus Directory
]
[
Site Map ]
©2002-2008 by the UCSF Oral Pathology
Diagnostic Services, all rights reserved. Please contact Nusi.Dekker@ucsf.edu
if you have questions regarding this site. Last updated April 11,2008.
Back to Oral
Pathology Home Page