Andrej Sali, Ph.D.
Professor of Biopharmaceutical Sciences and Pharmaceutical Chemistry

Contact Information:
sali@salilab.org
Tel: (415) 514-4227
Fax: (415) 514-4231
Box 2552, MB, QB3,
Floor 5 South 503B

Links:
Lab Website
California Institute for Quantitative Biomedical Research

Publications

Bioinformatics, Computational Biology, Protein Structure Theory

We are interested in using computation grounded in the laws of physics and the theory of evolution to study the structure and function of proteins. We aim to improve and apply methods for:

1. predicting the structures of proteins;

2. determining the structures of macromolecular assemblies;

3. annotating the functions of proteins using their structures.

This research contributes to structure-based functional annotation of proteins and thus enhances the impact of genome sequencing, structural genomics, and functional genomics on biology and medicine.


Selected Publications
1. A. Sali, T.L. Blundell. Comparative protein modelling by satisfaction of spatial restraints. J. Mol. Biol. 234, 779-815, 1993.

2. A. Sali, E.I. Shakhnovich, M. Karplus. How does a protein fold?. Nature 369, 248-251, 1994.   

3. R. Sánchez, A. Sali. Large-scale protein structure modeling of the Saccharomyces cerevisiae genome. Proc. Natl. Acad. Sci. USA 95, 13597-13602, 1998.  

4. D. Baker, A. Sali. Protein structure prediction and structural genomics. Science 294, 93-96, 2001.  

5. U. Pieper, N. Eswar, A.C. Stuart, V.A. Ilyin, A. Sali. MODBASE, a database of annotated comparative protein structure models. Nucleic Acids Research 30, 255-259, 2002.   

6. A. Sali, R. Glaeser, T. Earnest, W. Baumeister. From words to literature in structural proteomics. Nature 422, 216-225, 2003.