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Roger Brent, Ph.D. |
The
Alpha Project. The flagship activity at the Molecular Sciences Institute is the "Alpha project." The goal of the project is to gain the ability to predict the behavior of a well-studied biological regulatory system at the level of individual cells. The system is the G-protein receptor coupled signal transduction pathway that governs the response of haploid MATa S. cerevisiae to the mating pheromone, a factor. This pathway is a prototype for regulatory networks that govern response to external stimuli in higher eukaryotes. It is sufficiently tractable to facilitate development of numerous functional genomic experimental and computational methods; and sufficiently paradigmatic so that successful experimental and computational tactics can be ported rapidly to other systems in other organisms. The subgoals of this work are to: 1) Develop experimental means to measure system output and key intermediate quantities from single cells and populations of cells. 2) Develop computational means to simulate the behavior of cells and populations of cells. 3) Use these methods to build models that predict the quantitative behavior of cells in over time in response to defined perturbations. 4) learn to perform combined experimental work and learning to develop investigators in a multidisciplinary genomic research environment. The Alpha project is an ambitious, multidisciplinary genomic research program that is projected to continue until at least 2007. The work involves researchers from mathematics, physics, and computer science, and interaction with labs at MIT, Caltech, UC Berkeley, and Pacific Northwest National Labs. Genomic experimental methods. Researchers at the Institute are also continuing to develop means to identify proteins involved in biological processes and to ascribe functional significance to protein- protein interactions. New
Directions: |
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Copyright © 2005 The Regents of the University of California. Last updated: September 22, 2005 |