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Linda Noble, PhD
Neurobiology of CNS Injury
Selected Publications | Complete Publications

phone
(415) 476-4850
email
Linda.Noble@ucsf.edu
additional
websites

Department of Neurological Surgery

secondary
research affiliation
none
Functional recovery after traumatic brain and spinal cord injury is not simply the consequences of the initial mechanical destruction of tissue but is also attributed to the evolution of complex secondary events that contribute to early as well as delayed cell injury. Our laboratory employs experimental models of traumatic brain and spinal cord injury in the rodent to study the early events that contribute to cell injury and impair functional recovery. We are focused on the role of the blood-brain and spinal cord barrier in early pathogenesis after traumatic injury, the acute and chronic influences of inflammation on both injury and repair mechanisms, and the identification of those cellular defense mechanisms, intrinsic to the brain and spinal cord, that protect against secondary injury and may be essential for limiting the extent of cell injury.

Selected Publications

Noble LJ, Donovan F, Igarashi T, Goussev S, Werb Z. Matrix metalloproteinases limit functional recovery after spinal cord injury by modulation of early vascular events. J. Neuroscience, 22 7526-7535, 2002.

Chang E, Wong R, Vreman H, Galo E, Sharp F, Igarashi T, Stevenson D, and Noble-Hauesslein, L.J. Heme oxygenase protects against lipid peroxidation-mediated cell loss and impaired motor recovery after traumatic brain injury. J Neuroscience, .23:3689-96, 2003.

Goussev S, Hsu JY, Lin Y, Tjoa I, Maida N, Werb Z, Noble-Hauesslein, LJ. Differential temporal expression of matrix metalloproteinases after spinal cord injury: relationship to revascularization and wound healing. J Neurosurg., 99(2 Suppl):188-97, 2003.

Whetstone W, Eisenberg M, Werb Z, and Noble-Hauesslein, LJ.. The blood-spinal cord barrier after spinal cord injury: Relation to revascularization and wound healing. J Neurosci Res., 74:227-239, 2003.

Yamauchi T, Lin Y, Sharp F, Noble-Hauesslein, LJ. Hemin induces heme oxygenase-1 in spinal cord vasculature and attenuates barrier disruption and neutrophil infiltration in the injured murine spinal cord. J Neurotrauma, 21:1017-30, 2004.

Chang E, Claus C, and Noble-Haeusslein LJ. Regulation of heme after traumatic brain injury: The role of heme oxygenases. Journal of Cerebral Blood Flow and Metabolism, 27:169-75, 2005.

Trivedi A, Igarashi T, Compagnone N, Fan X, Hsu J, Hall D, John C, and Noble-Haeusslein L. Allogenic sertoli cells as a vehicle for the delivery of human neurotrophin-3 to the injured spinal cord. Experimental Neurology. 198:88-100, 2006.

Potts M, Koh, S-E, Whetstone W, Walker B, Yoneyama T, Claus C, Manvelyan H, and Noble-Haeusslein L J. Traumatic injury to the developing brain: Strategies to limit early damage and restore function. NeuroRx. 3:143-53, 2006.

Trivedi A, Olivas A, and Noble-Haeusslein LJ. Inflammation and spinal cord injury: Infiltrating leukocytes as determinants of injury and repair processes. (In Press, Clinical Neuroscience Research).

Pullela R, Raber J, Ferriero D, Claus C, Koh S, Yamauchi T, Rola R, Fike J, and Noble-Haeusslein L J. Traumatic injury to the developing brain results in progressive neuronal loss, hyperactivity, and delayed cognitive impairments. (In Press, Developmental Neuroscience).

information last updated June 2006


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