Biomedical Sciences Graduate Program | University of California, San Francisco

Biomedical Sciences (BMS) Graduate Program

BMS Research Areas

Cancer Biology &
Cell Signaling

Developmental &
Stem Cell Biology

Human Genetics

Immunology

Neurobiology

Tissue/Organ Biology & Endocrinology

Vascular & Cardiac Biology

Virology & Microbial Pathogenesis

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Matthew Krummel, PhD
Molecular Coordination in Multipartite Interactions

Selected Publications | Complete Publications

phone	(415) 514-3130
email	Matthew.Krummel@ucsf.edu
additional websites	Lab Website Cancer Center
secondary research affiliation	Cancer Biology & Cell Signaling

Multiple intercellular contacts give rise to the complex systems behavior of
the immune system. We are extending our imaging systems in order to study
interactions amongst a variety of T cell partners such as dendritic cells and
macrophages. Of particular interest are the multipartite interactions in
which three or more cells come together simultaneously or sequentially to
create complex biology. Novel biological insights can be gleaned by
understanding the nature of cooperative and competitive cellular interactions. In addition, we are using molecular genetics coupled with imaging to identify novel molecular players recruited to immune cell-cell interfaces. Our ultimate goal is to uncover the methods by which the immune system regulates the decision between tolerance and immunity

Selected Publications

Jacobelli, J. Chmura, S.A., Buxton,D.B., Davis , M.M. and Krummel, M. F. 2004. A single class II myosin modulates T cell motility and stopping, but not synapse assembly . Nature Immunology 5, 531 - 538

Boisvert, J., Edmondson, S. and Krummel, M.F. 2004. Immunological Synapse Formation Licenses CD40-CD40L Accumulations at T-APC Contact Sites. J. Immunol. 173, 3647-3652.

Tang, Q., Adams, J.Y., Tooley, A.J., Bi, M., Serra, P., Santamaria, P., Krummel, M.F .* and Bluestone, J.A.* 2006. Visualizing regulatory T cell control of autoimmune response in NOD diabetic mice. Nature Immunolog y, 7, 83-92

Moldovan M-C, Sabbagh L, Breton G, Sekaly R.P.*and Krummel M.F. *. 2006. Triggering of T cell activation via CD4 dimers. J Immunol. 176(9 ):5438-45.

Friedman, R.S. Jacobelli, J, and Krummel, M.F. 2006. Su rface-bound Chemokines Capture and Prime T cells For Synapse Formation. Nature Immunology 7 , 1101-8.

Krummel, M.F. and Macara I. 2006. M aintenance and modulation of T cell polarity Nature Immunology. 7, 1143-49.

information last updated May 2007