Biomedical Sciences Graduate Program | University of California, San Francisco

Biomedical Sciences (BMS) Graduate Program

BMS Research Areas

Cancer Biology &
Cell Signaling

Developmental &
Stem Cell Biology

Human Genetics

Immunology

Neurobiology

Tissue/Organ Biology & Endocrinology

Vascular & Cardiac Biology

Virology & Microbial Pathogenesis

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Kathleen Giacomini, PhD
Pharmacogenomics of Membrane Transporters

Selected Publications | Complete Publications

phone	(415) 514-3802
email	kathy.giacomini@ucsf.edu
additional websites	Lab website
secondary research affiliation	Cancer Biology and Cell Signaling

Kathy Giacomini’s research focuses on targeting and disposition of drugs and on genetic variation in drug response. She is particularly interested in the role of membrane transporters in drug response. Her research has four areas of focus: (a) development of targeted drug therapies for cancer; (b) pharmacogenetics of drug-induced nephrotoxicity centered on anti-viral drugs; (c) the role of liver specific transporters in treatment and progression of fatty liver; and (d) the physiologic and pharmacologic role of nucleoside and nucleotide transporters. Her studies range from cellular and molecular studies of the mechanisms of membrane transport to translational studies in transgenic and knockout mice and clinical studies.

Selected Publications

Y. Shu, S. Sheardown, C. Brown, R Owens, S. Zhang, R. Castro, A. lanculescu, L. Yue, J. Lo, E. Burchard, C Brett, and KM Giacomin. Effect of genetic variation in the organic cation transported 1(OCT1) on metformin action. J Clin Invest. 117:1422-1431(2007).

M. Reitman and E Schadt. Pharmacogenetics of metformin response: a step in the path toward personalized medicine. J Clin Invest. 117:1226-1229 (2007)

T. Urban, R. Sebro, E. Hurowitz, M. Leabman, I. Badagnani, L. Lagpacan, N. Risch and K. Giacomini. Functional genomics of membrane transporter in human populations. Genome Research 16: 223-230, (2006)

Erdman AR, Mangravite LM, Urban TJ, Lagpacan LL, Castro RA, de la Cruz M, Chan W, Huang CC, Johns SJ, Kawamoto M, Stryke D, Taylor TR, Carlson EJ, Ferrin TE, Brett CM, Burchard EG, Giacomini KM. The human organic anion transporter 3 (OAT3; SLC22A8): genetic variation and functional genomics. Am J Physiol Renal Physiol. 2006 Apr;290(4):F905-12.

S. Zhang, K.S. Lovejoy, J.E. Shima, L.L. Lagpacan, Y. Shu, A. Lapuk, Y. Chen, T. Komori, J.W. Gray, X. Chen, S.J. Lippard ,* and K.M. Giacomini. Organic Cation Transporters Are Determinants of Oxaliplatin Cytotoxicity, Cancer Research (in press, 2006)

Owen, I. Badagnani, and K.M. Giacomini. Molecular Determinants of Specificity for Synthetic Nucleoside Analogs in the Concentrative Nucleoside Transporter, CNT2*, R.P. Journal of Biological Chemistry (in press, 2006)

T.J. Urban, N. Risch, and K.M. Giacomini. Haplotype Structure and Ethnic-Specific Allele Frequencies at the OCTN Locus: Implications for the Genetics of Crohn Disease. Inflammatory Bowel Diseases Journal, 11(1): 78-79 (2005).

M.K. Leabman, C.C. Huang, J. DeYoung, E.J. Carlson, T. Taylor, M. de la Cruz, S.J. Johns, D. Stryke, M. Kawamoto, T. J. Urban, D.L. Kroetz, T.E. Ferrin, A.G. Clark, N. Risch, I. Herskowtiz, and K.M. Giacomini. Natural Variation in Human Membrane Transporter Genes Reveals Evolutionary and Functional Constraints. Proc. Natl. Acad. Sci. 100:5896-901 (2003)

Y. Shu, M.K. Leabman, B. Feng, L.M. Mangravite, C.C. Huang, D. Stryke, M. Kawamoto, S.J. Johns, J. De Young, E. Carlson, T.E. Ferrin, I. Herskowitz, K.M. Giacomini, and Pharmacogenetics of Membrane Transporters Investigator.Evolutionary Conservation Predicts Function of Variants of the Human Organic Cation Transporter, OCT1. Proc. Natl. Acad. Sci. 100(10):5902-07 (2003).

information last updated May 2007