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Caroline Damsky, PhD
Adhesion Receptors in Morphogenesis and Signaling
Selected Publications | Complete Publications

phone
(415) 476-8922
email
damsky@cgl.ucsf.edu
additional
websites

Cancer Center
Tetrad Graduate Program
Department of Anatomy

secondary
research affiliation
Cancer Biology & Cell Signaling
The Damsky lab focuses on the role of cell- extracellular matrix (ECM) interactions in mammalian development, tissue remodeling, and cell signaling, with emphasis on the integrin family of ECM receptors. Processes and tissues of particular interest include: trophoblast differentiation and invasion during formation of the placenta; differentiation of osteoblasts during formation and remodeling of bone; and regulation of cell survival and cell growth in fibroblasts and endothelial cells. In all these systems signals from ECM, transduced by integrins, play critical roles in tissue formation and remodeling. Approaches used range from analysis of signaling pathways relevant to cell growth, survival and differentiation using cultured cells, to generation of transgenic animals expressing truncated forms of integrins or ECM components.

Selected Publications

Damsky , C.H. and Fisher, S.F. 1998. Trophoblast pseudovasculogenesis": faking it with endothelial adhesion receptors. Curr. Opin. in Cell Biol. 10: 660-665.

Almeida, E., Ilic, D., Han, Q. Hauck, C., Jin, F., Kawatatsu, H., Schlaepfer, D., Damsky , C. (2000) Matrix survival signaling: from fibronectin, via focal adhesion kinase, to JNK. J. Cell Biol. 149: 741- 754.

Zimmerman, DL., Jin, F., Leboy, p., Hardy, S and Damsky , CH (2000) Impaired bone formation in transgenic mice resulting from altered integrin function in osteoblasts. Develop. Biol. 220: 2-15.

Damsky, C.H. and Ilic, D. (2002) Signaling from Cell Adhesion receptors: it's where the action is. Curr. Opin. Cell Biol. 14:594-602.

Ilic, D, Kovacic, B., Jin, F., Baumbusch, C., Gardner, D. and Damsky ,C. (2003) FAK is required for blood vessel morphogenesis. Circulation Res., 92: 300-307.

Ilic,D . Kovacic B, Yohkura,K., Schlaepfer, D.D. Tomasevi C,N., Han, Q.,Kim, J-B., Howerton, K., Ogiwara, N., Streblow, DN, Nelson, J., Paul Dazin, P., Shino, Y., Sasaki, K. and Damsky , CH. (2004) FAK regulates organization of fibronectin matrix and fibrillar adhesions. J Cell Science. 117:177-187.

information last updated July 2004

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