Gene silencing by deletion and by aberrant methylation
are two predominant mechanisms of tumorigenesis, yet their interaction
is largely unknown. Our research brings together these genomic and
epigenomic perspectives of human tumorigenesis, primarily in human
brain and breast tumors. As a complementary approach to the tumor
studies, we investigate the role of normal methylation patterns in
human cells and tissues using a genome scanning method along with
custom bioinformatic tools. To facilitate these studies we are also
developing an array method for genome-wide methylation analysis. |
Zardo G; Tiirikainen M, Hong C; Misra A; Feuerstein
BG; Volik S; Collins CC; Lamborn KR; Bollen A; Pinkel D; Albertson,
DG; Costello JF. Integrated Genomic and Epigenomic Analyses Pinpoint
Biallelic Gene Inactivation in Tumors. Nature Genetics, 2002, 32(3):453-458.
Costello JF. DNA methylation in brain development
and gliomagenesis. Frontiers in Biosciences, 2003, 8: S175-S184.
Smiraglia DJ; Rush LJ; Frühwald M; Dai Z; Held
WA; Costello JF; Lang JC; Eng C; Li B; Wright FA; Caligiuri MA;
Plass C. Excessive CpG island hypermethylation in cancer cell lines
versus primary human malignancies, Human Molecular Genetics, 2001,
10: 1413-1419.
Costello JF; Frühwald MC; Smiraglia DJ; Rush L; Robertson GP;
Gao X; Wright FA; Feramisco JD; Peltomäki P; Lang JC; Schuller
DE; Yu L; Bloomfield CD; Caligiuri MA; Yates A; Nishikawa R; Huang
HJS; Petrelli NJ; Zhang X; O'Dorisio MS; Held WA; Cavenee WK; Plass
C. Aberrant CpG island methylation has non-random and tumor type-specific
patterns. Nature Genetics, 2000, 25:132-138.
Ching TT, Maunakea AK, Jun P, Hong C, Zardo G, Pinkel D, Albertson DG, Fridlyand J, Mao JH, Shchors K, Weiss WA, Costello JF. Epigenome analysis using BAC microarrays identify evolutionary conservation of tissue-specific methylation of SHANK3. Nat Genet. 2005 Jun;37(6):645-51.
information last updated September 2005 |
Biomedical Sciences (BMS) Graduate Program
